Intermediate filaments inCaenorhabditis elegans
نویسندگان
چکیده
منابع مشابه
Intermediate filaments
Intermediate filaments form a class of insoluble cytoplasmic filaments ofdimensions intermediate in size between those of microtubules (about 25 nm in diameter) and microfilaments (about 7 nm in diameter). Thus, they are generally known as intermediate-sized filaments (IF)' or 10-nm filaments. They have been identified in virtually all differentiated types ofcells and it seems possible that IF-...
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The metaphase to anaphase transition is a critical stage of the eukaryotic cell cycle, and, thus, it is highly regulated. Errors during this transition can lead to chromosome segregation defects and death of the organism. In genetic screens for temperature-sensitive maternal effect embryonic lethal (Mel) mutants, we have identified 32 mutants in the nematode Caenorhabditis elegans in which fert...
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Neurofilaments (NFs) are the most abundant structural components in large-diameter myelinated axons. Assembled as obligate heteropolymers requiring NF-L and substoichiometric amounts of NF-M and/or NF-H, NF investment into axons is essential for establishment of axonal caliber, itself a key determinant of conduction velocity. Use of transgenic mice to increase axonal accumulation of NFs or to e...
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The intermediate filament (IF) network is one of the three cytoskeletal systems in smooth muscle. The type III IF proteins vimentin and desmin are major constituents of the network in smooth muscle cells and tissues. Lack of vimentin or desmin impairs contractile ability of various smooth muscle preparations, implying their important role for smooth muscle force development. The IF framework ha...
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Eukaryotic cells feature two ubiquitous fibrous cytoskeletal polymers in their cytoplasm: F-actin and microtubules. A third fibrous polymer, intermediate filaments (IFs), appeared more recently in evolution (Fuchs and Cleveland, 1998; Erber et al., 1998). Two common traits define members of the family of IF proteins. First, these proteins exhibit a characteristic tripartite domain organization,...
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ژورنال
عنوان ژورنال: Cell Motility and the Cytoskeleton
سال: 2009
ISSN: 0886-1544,1097-0169
DOI: 10.1002/cm.20372